Flow induced regulation of PGE2

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For August we are highlighting a paper by Raheev Rohatgi and co-workers entitled “Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct”.  Listen along as Dr. Rohatgi and Editor-in-Chief Tom Kleyman discuss the role of tubular flow in activating phospholipase A2 and excretion of PGE2, and the role of PGE2 in regulating ion transport in collecting ducts.

Daniel Flores, Yu Liu, Wen Liu, Lisa M. Satlin, and Rajeev Rohatgi. Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct. Am J Physiol Renal Physiol; published ahead of print June 13, 2012, doi:10.1152/ajprenal.00169.2012

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ENaC inhibition stimulates Cl- secretion in mouse CCD

Pech001.jpgOur July 2012 podcast highlights a paper published by Dr. Valdimir Pech and his colleagues entitled “ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism”. Join us as Editor-in-Chief Thomas Kleyman and Vladimir Pech discuss  the role of electrogenic Na+ absorption in Cl- absorption, and how Dr. Pech's work contrasts with previous studies addressing Cl- absorption in the CCD.

Vladimir Pech, Monika Thumova, Young Hee Kim, Diana Agazatian, Edith Hummler, Bernard C. Rossier, Alan M. Weinstein, Masayoshi Nanami, and Susan M. Wall. ENaC inhibition stimulates Cl secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanisn. Am J Physiol Renal Physiol July 1, 2012 303:F45-F55; published ahead of print April 11, 2012, doi:10.1152/ajprenal.00030.2012

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