In vivo proteolytic activation of γENaC by aldosterone/ Serine protease inhibitors

KenichiroKitamura.jpgOur October 2012 podcast highlights work by Dr. Kenichiro Kitamura and his colleagues at Kumamoto University Graduate School of Medical Sciences. They have recently published two papers in AJP: Renal Physiology: “In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats” and “Effect of a serine protease inhibitor on the progression of chronic renal failure.” Join Editor-in-Chief Thomas Kleyman and Dr. Kitamura as they discuss the role of serine proteases in the progressive loss of kidney function in a rat model of CKD, and in the activation of ENaC.

Kohei Uchimura, Yutaka Kakizoe, Tomoaki Onoue, Manabu Hayata, Jun Morinaga, Rika Yamazoe, Miki Ueda, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Yoshiki Sakai, Kimio Tomita, and Kenichiro Kitamura. In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats Am J Physiol Renal Physiol October 1, 2012 303:F939-F943; published ahead of print July 25, 2012, doi:10.1152/ajprenal.00705.2011

Manabu Hayata, Yutaka Kakizoe, Kohei Uchimura, Jun Morinaga, Rika Yamazoe, Teruhiko Mizumoto, Tomoaki Onoue, Miki Ueda, Naoki Shiraishi, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, and Kenichiro Kitamura.Effect of a serine protease inhibitor on the progression of chronic renal failure Am J Physiol Renal Physiol; published ahead of print July 25, 2012, doi:10.1152/ajprenal.00706.2011

00:0000:00