Episodes
Wednesday Dec 05, 2012
Drosphilia Kidney Stones
Wednesday Dec 05, 2012
Wednesday Dec 05, 2012
Our AJP-Renal December podcast focuses on a manuscript describing the use of Drosophila to explore the role of a specific transport protein in the genesis of kidney stones. Join Dr. Kleyman as he discusses this new model system with Dr. Michael Romero and Dr. Julian Dow.
Dr. Michael Romero Dr. Julian Dow
Taku Hirata, Pablo Cabrero, Donald S. Berkholz, Daniel P. Bondeson, Erik L. Ritman, James R. Thompson, Julian A. T. Dow, and Michael F. Romero. In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 303: F1555-F1562; published ahead of print September 19, 2012, doi:10.1152/ajprenal.00074.2012.
Thursday Oct 11, 2012
In vivo proteolytic activation of γENaC by aldosterone/ Serine protease inhibitors
Thursday Oct 11, 2012
Thursday Oct 11, 2012
Our October 2012 podcast highlights work by Dr. Kenichiro Kitamura and his colleagues at Kumamoto University Graduate School of Medical Sciences. They have recently published two papers in AJP: Renal Physiology: “In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats” and “Effect of a serine protease inhibitor on the progression of chronic renal failure.” Join Editor-in-Chief Thomas Kleyman and Dr. Kitamura as they discuss the role of serine proteases in the progressive loss of kidney function in a rat model of CKD, and in the activation of ENaC.
Kohei Uchimura, Yutaka Kakizoe, Tomoaki Onoue, Manabu Hayata, Jun Morinaga, Rika Yamazoe, Miki Ueda, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Yoshiki Sakai, Kimio Tomita, and Kenichiro Kitamura. In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats Am J Physiol Renal Physiol October 1, 2012 303:F939-F943; published ahead of print July 25, 2012, doi:10.1152/ajprenal.00705.2011
Manabu Hayata, Yutaka Kakizoe, Kohei Uchimura, Jun Morinaga, Rika Yamazoe, Teruhiko Mizumoto, Tomoaki Onoue, Miki Ueda, Naoki Shiraishi, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, and Kenichiro Kitamura.Effect of a serine protease inhibitor on the progression of chronic renal failure Am J Physiol Renal Physiol; published ahead of print July 25, 2012, doi:10.1152/ajprenal.00706.2011
Thursday Jul 26, 2012
Flow induced regulation of PGE2
Thursday Jul 26, 2012
Thursday Jul 26, 2012
For August we are highlighting a paper by Raheev Rohatgi and co-workers entitled “Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct”. Listen along as Dr. Rohatgi and Editor-in-Chief Tom Kleyman discuss the role of tubular flow in activating phospholipase A2 and excretion of PGE2, and the role of PGE2 in regulating ion transport in collecting ducts. Daniel Flores, Yu Liu, Wen Liu, Lisa M. Satlin, and Rajeev Rohatgi. Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct. Am J Physiol Renal Physiol; published ahead of print June 13, 2012, doi:10.1152/ajprenal.00169.2012
Thursday Jul 05, 2012
ENaC inhibition stimulates Cl- secretion in mouse CCD
Thursday Jul 05, 2012
Thursday Jul 05, 2012
Our July 2012 podcast highlights a paper published by Dr. Valdimir Pech and his colleagues entitled “ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism”. Join us as Editor-in-Chief Thomas Kleyman and Vladimir Pech discuss the role of electrogenic Na+ absorption in Cl- absorption, and how Dr. Pech's work contrasts with previous studies addressing Cl- absorption in the CCD.
Vladimir Pech, Monika Thumova, Young Hee Kim, Diana Agazatian, Edith Hummler, Bernard C. Rossier, Alan M. Weinstein, Masayoshi Nanami, and Susan M. Wall. ENaC inhibition stimulates Cl− secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanisn. Am J Physiol Renal Physiol July 1, 2012 303:F45-F55; published ahead of print April 11, 2012, doi:10.1152/ajprenal.00030.2012
Thursday Jun 14, 2012
RAS in Glomerular Endothelial Cells
Thursday Jun 14, 2012
Thursday Jun 14, 2012
For our June Podcast, we join associate editor Darwin Bell as he speaks with Juan Carlos Velez of The Medical University of South Carolina about his recently published paper, “Enzymatic Processing of Angiotensin Peptides by Human Glomerular Endothelial Cells”. Listen in as they discuss the processing of angiotensin by glomerular endothelial cells.
Juan Carlos Q Velez, Jessalyn L Ierardi, Alison M Bland, Thomas A. Morinelli, John M Arthur, John R. Raymond, and Michael G. Janech. Enzymatic Processing of Angiotensin Peptides by Human Glomerular Endothelial Cells . Am J Physiol Renal Physiol; published ahead of print March 28, 2012, doi:10.1152/ajprenal.00087.2012
Thursday May 03, 2012
PKCα and Urea Transport
Thursday May 03, 2012
Thursday May 03, 2012
In our newest podcast, Editor in Chief Thomas Kleyman interviews senior author and past Editor in Chief Jeff Sands along with lead author Janet Klein (Emory University) about the dual phosphorylation pathways that regulate urea transporter activity in the kidney inner medulla.
Janet D. Klein, Christopher F. Martin, Kimilia J. Kent, and Jeff M. Sands. Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct. Am J Physiol Renal Physiol May 1, 2012 302:F1098-F1103; published ahead of print February 1, 2012, doi:10.1152/ajprenal.00664.2011
Monday Apr 16, 2012
NHE3 regulates calcium homeostasis
Monday Apr 16, 2012
Monday Apr 16, 2012
Listen as Associate Editor Susan Wall and Dr. Todd Alexander discuss mechanisms of calcium absorption in the nephron and Dr. Alexander's recent publication in AJP-Renal, “THE EPITHELIAL SODIUM-PROTON EXCHANGER, NHE3, IS NECESSARY FOR RENAL AND INTESTINAL CALCIUM (RE)ABSORPTION.” Wanling Pan,Jelena Borovac,Zachary Spicer,Joost G. Hoenderop,René J. Bindels,Gary E. Shull, Michael R. Doschak, Emmanuelle Cordat, and R. Todd Alexander.The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol April 15, 2012 302:F943-F956; published ahead of print September 21, 2011, doi:10.1152/ajprenal.00504.2010
Thursday Mar 22, 2012
Regulation of the Pendrin Gene by Uroguanylin
Thursday Mar 22, 2012
Thursday Mar 22, 2012
In our second Podcast of March, the manuscript “The Pendrin Anion Exchanger Gene is Transcriptionally Regulated by Uroguanylin: A Novel Entero-Renal Link” is discussed by Associate Editor Susan Wall and Prof. Israel Zelikovic. Listen in as they speak on a novel enterorenal link - transcriptional regulation of the pendrin anion exchanger gene by uroguanylin via a heat shock system-dependent mechanism.
Julia Rozenfeld, Osnat Tal, Orly Kladnitsky, Lior Adler, Edna Efrati, Stephen L. Carrithers, Seth L. Alper, and Israel Zelikovic. The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link. Am J Physiol Renal Physiol March 1, 2012 302:F614-F624; published ahead of print November 30, 2011, doi:10.1152/ajprenal.00189.2011
Monday Mar 05, 2012
Unanswered Questions- Autoregulation
Monday Mar 05, 2012
Monday Mar 05, 2012
This is the first podcast by AJP:Renal addressing the important unanswered questions remaining in renal physiology. The purpose of this series is to give students, postdocs and junior faculty access to the ideas of leaders in their field. In this podcast William Arendshorst and Christopher Wilcox will discuss the big questions remaining to be solved in the field of autoregulation of renal blood flow. They address the mechanisms involved and how they are altered in pathological states.
Wednesday Feb 01, 2012
Endogenous Adenosine in Renal Sympathetic Neurotransmission
Wednesday Feb 01, 2012
Wednesday Feb 01, 2012
Join us as Jeffrey Garvin, Associate Editor of AJP:Renal, leads Edwin Jackson from The University of Pittsburgh Department of Pharmacology and Chemical Biology in a exciting discussion of his group’s latest findings. Does Adenosine influence renal sympathetic nerve stimulation in the kidney?
Edwin K. Jackson, Dongmei Cheng, Stevan P Tofovic, and Zaichuan Mi. Endogenous Adenosine Contributes to Renal Sympathetic Neurotransmission Via Postjunctional A1-Receptor-Mediated Coincident Signaling. Am J Physiol Renal Physiol; published ahead of print November 23, 2011, doi:10.1152/ajprenal.00495.2011