AJP-Renal Physiology would like to recognize an important article out this month by Kelli Sas and her colleagues entitled, HYPERGLYCEMIA IN THE ABSENCE OF CILIA ACCELERATES CYSTOGENESIS AND INDUCES RENAL DAMAGE.

Listen in as Associate editor Jennifer Sullivan and Dr. Sas discuss how hyperglycemia, in the absence of cilia, results in renal structural and functional damage and accelerates cystogenesis, suggesting that diabetes is a risk factor for the progression of polycystic kidney disease.

Sex differences in ET-1 receptors in IMCD

In October, we are highlighting a paper just published under our Renal Hemodynamics: Integrating with the Nephron and Beyond call for papers.  Please listen in as associate editor Anita Layton discusses "Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD." with authors David Pollock and Paul O'Connor.

Anti-fibrotic effect of proximal tubule PPARalpha

In September, we would like to highlight a paper from our most recent chronic kidney disease and fibrosis call.  Associate Editor Jennifer Sullivan and Dider Portilla of The University of Arkansas for Medical Sciences will discuss his group's recent AJP-Renal publication, "Proximal tubule PPARalpha attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction."

HO-1 prevents mitochondria dysfunction during hypoxia

For our August podcast, Editor in Chief Darwin Bell will be discussing with Subhashini Bolisetty of The University of Alabama at Birmingham, their group's latest paper which looks at the effects of Mitochondria-targeted heme oxygenase-1.

AJP-Renal Welcomes a new Editor in Chief

On July 1, AJP-Renal welcomed our new Editor in Chief Darwin Bell along with a new associate editor team and editorial board.  Please listen in as outgoing Editor in Chief, Thomas Kleyman and Dr. Bell discuss the future of AJP-Renal Physiology.

Glucocorticoids and Podocyte Progenitors

Our editor in chief elect Dr. Darwin Bell and Dr. Stuart Shankland of the University of Washington School of Medicine will be joining us for the June 2013 AJP-Renal Podcast.  Tune in as they discuss their findings as to how prednisone may improve outcomes in FSGS.

Jiong Zhang, Jeffrey W. Pippin,Ronald D. Krofft,Shokichi Naito,Zhi-Hong Liu,and Stuart J. Shankland. Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSG. Am J Physiol Renal Physiol June 1, 2013 304:F1375-F1389; published ahead of print March 13, 2013, doi:10.1152/ajprenal.00020.2013

Hydrodynamic Gene Delivery in the Kidney

Join Associate Editor Gerald Apodaca as he hosts Dr. Simon Atkinson and Peter Corridon for our May 2013 AJP-Renal podcast.  They will be discussing their method which employs hydrodynamic forces to facilitate transgene expression in rat kidneys.

Peter R. Corridon,George J. Rhodes,Ellen C. Leonard,David P. Basile,Vincent H. Gattone II,Robert L. Bacallao,and Simon J. Atkinson. A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vector. Am J Physiol Renal Physiol May 1, 2013 304:F1217-F1229; published ahead of print March 6, 2013, doi:10.1152/ajprenal.00070.2013

NBCe1-A substrate specificity


April showers bring May flowers and at AJP-Renal, our April podcast brings about a lively discussion between Editor in Chief Thomas Kleyman and Dr. Mark Parker of Case Western Reserve University  about his and his colleagues findings using a heterologous expression system to examine the substrate specificity of the sodium bicarbonate  co-transporter SLC4A4. Please listen in.....

Seong-Ki Lee,Walter F. Boron,and Mark D. Parker.Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbit. Am J Physiol Renal Physiol April 1, 2013 304:F883-F899; published ahead of print January 16, 2013, doi:10.1152/ajprenal.00612.2012

Low Salt Doesn’t Augment Intratubular AGT and Ang II in Rats

navar.jpgThis month's podcast features Associate editor Dr. Darwin Bell and Dr. Gabriel Navar of Tulane  discussing the results of activation of the Renin-Angiotensin system by low salt in rats. This  paper is highlighted in the March 2013 issue of AJP-Renal.

Weijian Shao,Dale M. Seth,Minolfa C. Prieto,Hiroyuki Kobori,and L. Gabriel Navar. Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats. Am J Physiol Renal Physiol March 1, 2013 304:F505-F514; published ahead of print January 9, 2013, doi:10.1152/ajprenal.00587.2012

HSP-70-induced immune reactivity causes hypertension


February's issue of AJP-Renal brings us a very interesting article by Dr. Bernardo Rodriquez-Iturbe and his group on heat shock protein 70.  Join associate editor Jeffery Garvin and Dr. Rodriquez-Iturbe as they discuss it's affects on immune response.

Héctor Pons, Atilio Ferrebuz, Yasmir Quiroz, Freddy Romero-Vasquez, Gustavo Parra, Richard J. Johnson, and Bernardo Rodriguez-Iturbe. Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension. Am J Physiol Renal Physiol February 1, 2013 304:F289-F299; published ahead of print October 24, 2012, doi:10.1152/ajprenal.00517.2012