Episodes
Tuesday Jan 03, 2012
WTIP regulates podocyte cell-cell and cell-matrix junctions
Tuesday Jan 03, 2012
Tuesday Jan 03, 2012
Listen in as AJP-Renal kicks off the new year with a brand new podcast featuring our Editor- in-Chief Thomas Kleyman, Dr. John Sedor and Dr. Jane Kim of Case Western Reserve University. They will discuss their recent findings involving the WT1-interacting protein.
Jane H. Kim, Amitava Mukherjee, Sethu M. Madhavan, Martha Konieczkowski, and John R. Sedor. WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization. Am J Physiol Renal Physiol January 2012 302:F103-F115; published ahead of print September 7, 2011, doi:10.1152/ajprenal.00419.2011
Monday Dec 05, 2011
Increased Urinary Renin Excretion in Ang II Hypertension
Monday Dec 05, 2011
Monday Dec 05, 2011
In our final AJP-Renal Podcast for 2011, Dr. Kleyman and Associate Editor Darwin Bell discuss with Minolfa Prieto her newest publication and our featured article : “Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.”
Liu Liu, Alexis A. Gonzalez, Michael McCormack, Dale M. Seth, Hiroyuki Kobori, L. Gabriel Navar, and Minolfa C. Prieto. Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats. Am J Physiol Renal Physiol December 2011 301:F1195-F1201; published ahead of print August 24, 2011, doi:10.1152/ajprenal.00339.2011
Editorial Focus
Jia L. Zhuo. Augmented intratubular renin and prorenin expression in the medullary collecting ducts of the kidney as a novel mechanism of angiotensin II-induced hypertension. Am J Physiol Renal Physiol December 2011 301:F1193-F1194; published ahead of print October 12, 2011, doi:10.1152/ajprenal.00555.2011
Thursday Nov 03, 2011
Tolvaptan inhibits AVP-induced proliferation of ADPKD cells
Thursday Nov 03, 2011
Thursday Nov 03, 2011
For our November 2011 podcast listen in as Associate Editor Lisa Satlin discusses our featured article, "Tolvaptan inhibits ERK-dependent cell proliferation, Cl- secretion and in vitro cyst growth of human ADPKD cells stimulated by vasopressin" with Darren Wallace of The University of Kansas Medical Center. Dr. Wallace has put together a very exciting study as his group examined the effects of graded concentrations of tolvaptan on AVP-induced cAMP production, ERK-mediated cell proliferation, Cl- secretion and in vitro cyst growth of human ADPKD cyst epithelial cells. Gail A. Reif, Tamio Yamaguchi, Emily Nivens, Hiroyuki Fujiki, Cibele S. Pinto, and Darren P. Wallace. Tolvaptan inhibits ERK-dependent cell proliferation, Cl- secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. Am J Physiol Renal Physiol November 2011 301:(5) F1005-F1013; published ahead of print August 3, 2011, doi:10.1152/ajprenal.00243.2011
Thursday Oct 06, 2011
Dale Benos Review Article Series
Thursday Oct 06, 2011
Thursday Oct 06, 2011
For the second of our two October podcasts, AJP:Renal Editor in Chief Thomas Kleyman, AJP:Cell Editor in Chief Paul Insel and APS Executive Director Martin Frank discuss a new series of review articles that highlight areas of research that were a focus of Dale Benos, who passed away in the fall of 2010. Join us as they reminisce about Dale's career and his contributions to the American Physiological Society and to the education of the next generation of physiologists. Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos Thomas R. Kleyman, Editor-in-Chief -AJP-Renal Physiology Departments of Medicine and of Cell Biology and Physiology University of Pittsburgh, Pittsburgh, PA Paul A. Insel, Editor-in-Chief-AJP-Cell Physiology Departments of Pharmacology and Medicine University of California, San Diego, La Jolla, CA Martin Frank, Executive Director Review Ossama B. Kashlan and Thomas R. Kleyman. ENaC structure and function in the wake of a resolved structure of a family member. Am J Physiol Renal Physiol October 2011 301:(4) F684-F696; published ahead of print July 13, 2011, doi:10.1152/ajprenal.00259.2011
Tuesday Oct 04, 2011
Hemodynamic responses following fistula creation
Tuesday Oct 04, 2011
Tuesday Oct 04, 2011
For the first of our two October podcasts, join Editor in Chief Thomas Kleyman and Associate Editor Karl Nath from Mayo Clinic as they discuss his group's recent work regarding changes in vascular hemodynamics in response to an arteriovenous fistula. Karl also addresses the role of heme oxygenase-1 in the adaptive response to an AV fistula.
Lu Kang, Satsuki Yamada, Melissa C. Hernandez, Anthony J. Croatt, Joseph P. Grande, Julio P. Juncos, Gregory M. Vercellotti, Robert P. Hebbel, Zvonimir S. Katusic, Andre Terzic, and Karl A. Nath. Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula. Am J Physiol Renal Physiol October 2011 301:(4) F845-F851; published ahead of print June 22, 2011, doi:10.1152/ajprenal.00311.2011Friday Sep 02, 2011
GLUT1 enhances mTOR activity
Friday Sep 02, 2011
Friday Sep 02, 2011
In September's podcast Frank Brosius III (Michigan) discusses his group's recent work regarding a link between increases in cellular glucose uptake via Glut1 and activation of the mTOR signaling pathway. Join Editor in Chief Thomas Kleyman and Associate Editor Kumar Sharma as they discuss with Dr. Brosius cellular mechanisms of mTOR activation and the role of mTOR in glomerular hypertrophy and fibrosis in diabetes. Carolyn L. Buller, Charles William Heilig, and Frank C. Brosius III. GLUT1 ENHANCES mTOR ACTIVITY INDEPENDENTLY OF TSC2 AND AMPK. Am J Physiol Renal Physiol, published ahead of print May 25, 2011, doi:10.1152/ajprenal.00472.2010.
Wednesday Aug 31, 2011
Role of the USF1 transcription factor in diabetic kidney disease
Wednesday Aug 31, 2011
Wednesday Aug 31, 2011
For our August Podcast, we join our Editor-in-Chief, Thomas Kleyman and Associate Editor Kumar Sharma as they discuss a recent AJP publication from Dr. Sharma's group regarding the transcription factor USF-1 and its role in diabetic nephropathy. Amber P. Sanchez, JingHong Zhao, Young You, Anne-Emilie Declèves, Maggie Diamond-Stanic, and Kumar Sharma. Role of the USF1 transcription factor in diabetic kidney disease. Am J Physiol Renal Physiol 301: F271-F279, 2011.
Friday Jul 22, 2011
Sphingosine-1-phosphate and Renal Na Handling
Friday Jul 22, 2011
Friday Jul 22, 2011
Dr. Ningjin Li from the Medical College of Virginia and his colleagues published a manuscript in our July 2011 issue of AJP-Renal Physiology entitled “A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate”. Listen as Dr. Li, Dr. Edwin Jackson from the University of Pittsburgh and our Editor-in-Chief, Thomas Kleyman discuss the role of sphingosine-1-phosphate in the regulation of renal Na handling.
Zhu Q, Xia M, Wang Z, Li PL, and Li N.
A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. Am J Physiol Renal Physiol (First published April 6, 2011). doi:10.1152/ajprenal.00014.2011.
Friday May 06, 2011
Cystogram in live mice by contrast ultrasound
Friday May 06, 2011
Friday May 06, 2011
Our May 2011 podcast highlights work by Dr. Carlton Bates and his colleagues at the University of Pittsburgh and Children’s Hospital of Pittsburgh. Their manuscript entitled “Assessing vesicoureteral reflux in live inbred mice via ultrasound with microbubble contrast agent” is published in the May 2011 issue of AJP-Renal Physiology. Editor-in-Chief Thomas Kleyman and Associate Editor Lisa Satlin discuss this novel method of assessing vesicoureteral reflux in live mice with Dr. Bates. Jose Paredes, Sunder Sims-Lucas, Hang Wang, Weining Lu, Brian Coley, George K Gittes, and Carlton M. Bates. Assessing vesicoureteral reflux in live inbred mice via ultrasound with microbubble contrast agent. Am J Physiol Renal Physiol 300: F1262-F1265, 2011.
Thursday Apr 07, 2011
GFR reduction and acid retention
Thursday Apr 07, 2011
Thursday Apr 07, 2011
Dr. Donald Wesson’s (Texas A&M Health Science Center, Scott and White Healthcare) recent work regarding the potential role of acid retention in increasing plasma levels of aldosterone and endothelin in the setting of moderate chronic kidney disease is the focus of our April 2011 Podcast. Enjoy the conversation between our Editor-in-Chief, Thomas Kleyman and Dr. Wesson as they discuss this exciting work. Accompanying this dialogue, we have an editorial focus written by Dr. Jeffrey Kraut (W. Los Angeles VA) that comments on Dr. Wesson's work. Donald E. Wesson, Jan Simoni, Kristine Broglio, and Simon Sheather. Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone. Am J Physiol Renal Physiol 300: F830-F837, 2011. Editorial Focus Jeffrey A. Kraut. Effect of metabolic acidosis on progression of chronic kidney disease. Am J Physiol Renal Physiol 300: F828-F829, 2011.